The probabilities of within- or between-class switches and discontinuations, as well as the persistence rate of the index triptan at the first refill within the 2-year follow-up period were similarly calculated.
A switch was defined as the discontinuation of index drug class and the addition of medication class not in the initial regimen prior to discontinuation with overlap ≤30 days or following discontinuation.
Subjects who did not complete the study either were lost to follow-up, moved to other cities, started university in another city, gone for military service, did not wish to continue to participate, or cited an intense schedule of classes as the reason for discontinuation.
The frequency of drug holidays in the short 100-day analysis periods are of particular concern since abrupt discontinuation of all classes of antidepressants, and especially short-acting serotonin uptake inhibitors, may trigger withdrawal reactions (Haddad 2001; Judge et al. 2002; Rosenbaum et al. 1998).
30 A retrospective study in the Netherlands detected an association of hospital-level class-specific antibiotic use, isolation discontinuation policy, disinfection solution and frequency and a few other infection prevention policies with aggregate hospital-level C. difficile rates.
The following sections organize ART modifications in patients with stably suppressed virus according to the ARV class of a drug that requires discontinuation and the ARV class of its replacement drug.
For example, the activity spectrum of antimicrobials was ranked against Gram-negative bacteria, with DE defined as a switch to or discontinuation of a drug class with a less-broad spectrum of coverage [ 5].
No difference was observed between the groups for change in NYHA class, β-blocker use, hospitalizations, treatment discontinuations or rescue medication use.
Multivariable logistic regression models were fit to compare the odds of being adherent, and multivariable Cox proportional hazards models were fit to compare time to discontinuation (persistence) between index drug classes and index drugs.
Discontinuation was measured at the drug class level for all cohort comparisons.
These events have been reported for rapid discontinuation of serotonergic antidepressants as a class [ 19].
