The two solutions could be superposed onto a trimeric model of g125 without sterical clashes (Figure 4).
Docking of L100754 in the ligand binding pocket of hRARα reveals that the ligand easily adapts to fit the RARα agonist conformation without significant steric clashes (Figure S4).
A two-structure superimposition showed that the N-lobe of RSK1 has enough room for the βB-sheet to be inserted without too many steric clashes (Figure 2B).
When the RU486 molecule is introduced in this way in the GR-LDB, 11-substituent diethyl amino group atoms and Leu753 (H12) side chain atoms overlap giving rise to sterical clashes (Figure S3B).
Based on the orientation of the ubiquitin protein in both structures, ISG15 easily fits into the catalytic domain of USP2, USP14, and USP5 (data not shown) without apparent steric clashes (Figure 7) [23], [43].
A recently solved 'near-rigor' conformation of the KIF14 motor (PDB 4OZQ) (Arora et al., 2014), found in a state that binds ADP but not magnesium, partially repairs the clash in Figure 5B by re-orienting the switch II helix to nearly the identical position (relative to the upper domain) as seen in our no-nucleotide model.
He began to make his name as a pugnacious -- some said sensationalistic -- interviewer on "Night Beat," a program shown on Channel 5 in New York City, and "The Mike Wallace Interview" on ABC -- famously roasting and clashing with news figures like the labor leader Michael J. Quill or celebrities like Barbra Streisand.
As a serial espouser of causes that were neither profitable or popular, Ms Peirce has inevitably clashed with powerful figures in the legal profession.
There had been open speculation for some time about what would happen after her contract with Fox expired, as her star rose in tandem with increasingly high-profile clashes with Republican figures.
Mr. Spanfeller said comScore's latest figures clashed with the company's internally generated data, which still showed about 15 million visitors a month, with ForbesAutos.com accounting for about 2 million of those.
