The role of autophagy in cancer is controversial and still not completely clarified: it has been described as a double-edged sword because of its involvement in both cell survival and tumor suppression, depending on cell type, genetic context, stage of tumor development and nature of the stressor [ 16, 17].
Although the biological factors underlying this extreme acceleration are not yet completely clarified, it is likely that adaptive evolution has played a significant role.
Although the mechanisms of these processes are not completely clarified, it is likely that DNA breakage at CFS may represent an initiating event.
Although the mechanisms involved in cell transformation by HTLV-1 have not been completely clarified, it is generally thought that Tax plays a pivotal role in the process.
The morbidity of DN is rising year by year with the increasing incidence and prevalence of diabetes dramatically and disproportionately, and the pathogenesis of DN has not been completely clarified; its treatment is limited, unsatisfactory, and expensive [ 3].
If you're unclear on the request, sprinkling in a few thoughtful, clarifying questions is completely appropriate too.
However, autophagy is so far considered as double-edged sword and its role is not completely clarified as it may act either cytoprotective or cytotoxic to cancer cells, for example, depending on the cell type and the environment.
The mechanism by which antioxidants are involved in vascular remodelling is not completely clarified, but it is known that polyphenols, like resveratrol, could protect NO from inactivation favouring its biologic activities [ 19].
Responding to Dalglish's comments, FA director of communications Adrian Bevington tweeted that it was "important to clarify Uefa has completely different set of disciplinary regulations to the FA".
It has been suggested that the histamine is produced in the atherosclerotic lesion although the activity of histamine has not been clarified completely.
Subanalyses of the JUPITER data published in Lancet helped clarify if not completely settle matters.
