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The reprogramming metabolomics combines response metabolome with reconstitution metabolome together to clarify response and reconstitution mechanisms and provide potential drugs for the purposes of disease prevention and treatment.
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This identified broad areas to be covered together with examples of suggested probes (see Box 1), although the interviewer was also free to follow up other issues that might arise and to probe and clarify responses.
The discussion was lively in each group and conversation was generally allowed to flow with intervention only to prompt participants to clarify responses, to challenge an individual to provide reasons for a position, or to offer an alternative view for the sake of stimulating the discussion.
If responses were still unclear, the interviewer contacted study participants by telephone to clarify responses.
Telephone interviews were used to clarify responses after initial data collection.
In order to facilitate subsequent scoring, interviewers are trained to clarify responses in several simple ways.
Participants were encouraged to give their points of view and to clarify responses.
Interviewers used probes to clarify responses and to obtain more detailed information.
The open response format of the questions in the guide allowed for probing to clarify responses and did not preclude respondents introducing other topics.
Open-ended initial questions on each domain and each item were followed-up with more specific queries to clarify responses and probe any confusing issues.
Both the CRF and structured questionnaire were reviewed prior to interviews and the information was used to probe and clarify responses provided by the patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com