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Moreover, data sources (clinical, preclinical, literature) and a method for assessing inter- and between-subject variability are clarified upfront.
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Importantly, BIG 1-98 is expected to provide more information on the benefits of switching to letrozole after 2 3 years of tamoxifen, and will clarify whether upfront or sequential AI use is the optimal strategy.
(3) The specific responsibilities of the Board and senior management in relation to the priority setting process should be clarified explicitly and upfront.
He agrees with Elliott and Resnik that policy-relevant scientific debates would be more productive and transparent if scientists disclosed their presumptions upfront, disclosed conflicts of interest, and clarified the pros and cons of multiple interpretations of the science.
However, given the limitations of our study, the real extent of possible benefits using additional boosting techniques like intraoperative radiation therapy compared to external beam radiation alone or neoadjuvant chemotherapy/chemoradiation compared to upfront surgery can only be further clarified in randomized trials.
VanderWaal further clarified that LG had been looking for a way to be upfront in the 4K market and found the option of streaming the concert for its customers as informative and lucrative.
The Delaware Supreme Court also clarified important open questions relating to the landmark MFW decision, which held that go-private mergers and other controlling stockholder transactions can avoid onerous "entire fairness" judicial scrutiny if they are conditioned "upfront" on approval by a fully disinterested special committee and the fully informed vote of a disinterested stockholder majority.
Contract clarified.
Gradilone clarified.
These studies, nevertheless, still have their own specific objectives, and these objectives need to be defined upfront (e.g., by clarifying what outcomes will be measured and defining any success/failure criteria).
A further advantage of clarifying details about the planned statistical analyses upfront is that, where applications for funding will be submitted, it may provide an opportunity to cost in time for any necessary statistical support that will be required, such as for regular integrated discussions with a statistician or for the dedicated statistical analysis.
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