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The continuing discovery of new G protein-coupled receptor (GPCR) interacting proteins and clarification of the functional consequences of these interactions has revealed multiple roles for these events.
Clearly, more studies will be required for clarification of the functional differences between TS1 and TS4 (Fig. 7).
A crucial next step in this process of evaluation would be further clarification of the functional meaning of ASWA.
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The clarification of the mechanism of EWS function may help to understand the functional molecular interactions in cancer, to find new partners and ways to treat cancer.
A planned follow-up study will allow further clarification of the determinants of mortality and functional decline among the oldest old.
We would like to see further study of the SCN neurophysiology related to LDLD-induced circadian bifurcation, including clarification of core-shell and anterior-posterior SCN functional differentiation, clarification of the SCN neuroanatomical structures, and exploration of which SCN-efferent neurotransmitters such as AVP and VIP mediate bifurcated secretion of melatonin when it occurs.
Given this clarification of functional GR expression in HBMEC/ciβ, the effects of RU486 on the Na-F permeability and TEER of these cells were examined.
The integration of the reported gene diversity with the functional physiological impacts requires the clarification of the SCD evolutionary path.
A clarification of the relationships between classes could help to delineate major functional shifts, yielding useful information for predicting the catalytic capabilities of uncharacterized GSTs.
The further clarification of the mechanisms of miRNA-mediated silencing and the requirements of functional miRNA target sites is an area of active research and will be important in understanding the physiological role of miRNA in diverse areas.
Concerning cnidarian neurogenesis, areas of particular interest for future studies include the clarification of the Notch-Delta signalling mechanism, and the exploration of expansion and functional diversification within the SoxB and Group A bHLH gene families.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com