Besides providing an understanding of the metabolic state in plants under various circumstances, metabolomic techniques are applicable to the clarification of the functions of unknown genes by using natural variants or mutants of the target plants.
Metabolomic techniques are applicable to develop useful rice cultivars having superior qualities and particularly for the clarification of the functions of valuable genes and safety assessment of GM rice.
For better clarification of the functions of qcd4-1 and qcd4-2, further studies are required to isolate a gene underlying QTL and to perform NIL experiments on different environments.
With the recent introduction of the concept of macrophage differentiation into M1 and M2 macrophages, and clarification of the function of each of these cell types, the role of TAMs in malignant tumors is gradually emerging.
Furthermore, in addition to the clarification of the function of single genes, metabolomics has the potential to determine the location of quantitative trait loci (QTL).
For clarification of a function of PINCH1 aside from FAs and whether other adapter proteins are key to the cellular radiation response remains to be solved in future examinations.
Further clarification of the function and endogenous ligands of TLR4 signaling in HSCs and other liver cells could uncover novel mechanisms of fibrogenesis and facilitate the development of therapeutic strategies.
Therefore, for the development of molecular-targeted anti-cancer drugs pinpointing cancer cells, identification of molecules that are expressed abundantly in cancer cells and clarification of their function are essential.
While results in this study also support the conclusion that RHD6 does not directly control transcription of EXP7, the functional role of EXP7 still needs clarification, since loss-of-function mutants do not display a phenotype [ 10].
