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Another subgroup of the clamped subjects (N = 150) additionally agreed to undergo an intravenous glucose tolerance test (IVGTT).
In a subgroup of the clamped subjects (N = 150), an IVGTT was performed prior to the clamp, as described by the Botnia protocol [15].
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The mean age of the 49 (24 and 25 subjects at centers 1 and 2, respectively) clamp study subjects was 47.6 years (range 27 64 years) and comprised 15 male and 34 female subjects.
Of 1293 clamped RISC subjects, 194 males and 205 females – median age 45 years and median body mass index (BMI) 25.0 kg m−2 (range 16.9 42.9) - were selected for non-targeted biochemical profiling analysis.
For the euglycemic clamp, subjects were connected to a Biostator (MTB Medizintechnik, Amstetten, Germany) in the morning, in the fasting state, ∼4 6 h before administration of the glargine test dose, as previously described (22).
The similar values obtained with the two populations suggest that the clamp study subjects are representative of the main population for measures of insulin resistance.
Within a single-center, double-blind euglycemic clamp study, subjects were randomized to receive single doses of 0.3, or 0.6, or 1.2 units · kg−1 glargine.
In a clamp study, subjects' blood glucose levels are kept within a specific range or under a certain threshold measurement by infusing intravenous glucose.
The constructs were clamped and subjected to flexure using a rigid spherical indenter.
The shell's ends are clamped and subjected to axial loading consisting of a static part and a harmonic part.
Simply supported and clamped beams subjected to four symmetric, equally spaced groups of equal point loads are analysed and formulae for their maximum deflections and moments are presented.
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