The latter measure was introduced to circumvent pitfalls of Up/Down classification, contingency tables and correlation coefficient that were discussed in the background section.
In addition we provide assistance for the design of biomarker studies to circumvent major pitfalls.
Table 3 summarizes some key points that should be considered for biomarker studies and highlights possible strategies and approaches to circumvent common pitfalls.
In addition, the analysis of ancient skulls provides direct biological evidence of past populations, thus circumventing the pitfalls intrinsic to any inferential approach (González-José et al. 2005b; Neves et al. 2005).
Appropriate statistical methods are required to evaluate such data sets and the use of biological databases helps to circumvent interpretational pitfalls.
In the light of these findings, alignment-free distance-based reconstruction methods deserve special attention, as they circumvent potential pitfalls of the multiple alignment approach, especially with respect to divergent sequences, and can be advantageous in speed possibly without sacrificing reconstruction accuracy.
To circumvent these pitfalls, we applied a random sampling strategy, similar to the one of Kim et al. to obtain AS rate estimations that are independent of EST amounts and distributions.
In order to circumvent this pitfall, plasma osmolarity should be the preferred monitoring parameter during the patient's management, as PNa may appear to increase while in fact plasma osmolarity is undergoing an expeditious decline, as glucose levels fall.
You can circumvent this pitfall by including people with diverse perspectives, different knowledge bases and skill sets, and who can fulfill different roles (e.g., devil's advocate, consensus builder, BS monitor).
One way of circumventing this pitfall is to replace the group of closely related sequences with their consensus.
Thus, one possible way to circumvent this pitfall would be to enroll at least a small comparator arm with complete pharmacokinetic characterization.
