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However, despite of the advantages such as simplicity of use, ease of large-scale production, and lack of specific immune response [13, 14], viral vectors might bring the side effects such as endogenous virus recombination, oncogenic effects, and unexpected immune response [15] while non-viral vectors could circumvent.
In recent years, some nonviral-based gene delivery systems, such as functional cationic polymers [3 5] and nano-carriers [6 8], circumvent some of the problems occurring with viral vectors such as endogeneous virus recombination, oncogenic effects, and unexpected immune response, but their gene transfer efficiency is inferior to viral vectors.
Given the unexpected behavior of the E populations, an identical experiment was established in a manner designed to circumvent the problems with insufficient cell density.
An unexpected room temperature Diels-Alder reaction occurred during the final step of the synthesis and was circumvented by use of an iodoacetamide conjugation moiety in place of a maleimide.
Computations ran into unexpected difficulties due to oscillations generated at material interfaces, and understanding of the underlying mechanisms was needed before these oscillations could be circumvented.
They circumvent our laws.
Too many parked cars to circumvent.
Some have proposed reforms to circumvent paralysis.
Not all the new devices circumvent incisions.
Rumsfeld evidently intended to circumvent that process.
Boxee has found ways to circumvent this.
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CEO of Professional Science Editing for Scientists @ prosciediting.com