Sentence examples for circumvent the challenges from inspiring English sources

This comprehensive review analyzes the beneficial characteristics and drawbacks of nucleosidic DNA methylation inhibitors, which will assist the pre-clinical and clinical researchers in the design of future experiments to improve the therapeutic efficacy of these drugs and circumvent the challenges in the path of successful epigenetic therapy.

To circumvent the challenges of in vitro and in vivo expansion of hMSCs, several ex vivo systems have been proposed.

Because they circumvent the challenges of a priori selection of particular regions in clinical trials, these novel methods may become useful tools in DMOAD trials [ 29].

This method of delivery might possibly circumvent the challenges that possibly exist with intravenous administration where tissue penetration is concerned, although this remains to be demonstrated objectively.

Radiolabeling the Zn-DPA targeting moiety with F and Cu for positron emission tomography and 99mTc and In for single-photon emission computed tomography may circumvent the challenges caused by fluorescent signals being attenuated in vivo.

This approach may circumvent the challenges of previous clinical trials based on organ of origin recruitment, in which there have been mixed results but some efficacy in individuals (see Additional file 11).

The present assay was designed to circumvent the challenge that these viruses represent for the specific detection of H5 subtype AI viruses.

To circumvent the challenge of ascertaining RNA expression in infected cells with waning levels of housekeeping genes, real-time PCR was performed using primers specific for the cPMLΔ5&6 transcripts along with primers that recognize all PML isoforms (primers derived from exon 3) to compare the expression of cPMLΔ5&6 to total PML transcripts during viral infection.

In this sense, combination therapy with forthcoming next-generation agents targeting resistance-associated mutations and pathways appears to be a helpful strategy to circumvent the challenge.

Different sequence alignment software packages have attempted to circumvent the challenge of assigning reads that map to multiple sites (termed multi-reads) [ 24- 29].

A recent approach to circumvent the challenge of tumor heterogeneity and to extract meaningful data from formalin-fixed tissue blocks has been suggested, combining matrix-assisted laser desorption ionization (MALDI) with imaging (MALDI imaging mass spectroscopy; MALDI-IMS).