c Minor: Minimal clinical significance, involving minimising risk, assessing risk and considering an alternative drug, taking steps to circumvent interaction risk and/or instituting a monitoring plan.
In order to explore PPIs in a quantitative manner, we have developed a method called PIE, to circumvent interaction enrichment biases in context-specific networks derived from general PPI networks.
While circumventing interaction, the MCS algorithm yielded a robust 2HBT1 effect.
Through the provision of such binding sites for commensal bacteria, the MGL can circumvent the interaction of pathogenic bacteria with the host cells and prevent further translocation of pathogens into the mucosa.
Interestingly, the continuous (5-day) exposure to paclitaxel and 5-fluorouracil had additive effects in A549, PA1 and WiDr cells, indicating that the prolonged simultaneous administration of these agents may circumvent the antagonistic interaction produced by short-term simultaneous administration.
An app that encourages cellphone use in the car -- no matter how ingeniously it circumvents normal smartphone interaction -- is sure to raise the hackles of those who want that kind of interaction banned.
These behavioural patterns suggest that the immaculata morph has evolved a strategy to circumvent male agonistic interactions and female mate choice (e.g., [ 5, 52, 53]).
Although concurrent administration of PXR antagonists with traditional chemotherapeutic drugs may circumvent drug-drug interactions and toxicities, the consideration of documented bone demineralization, unanticipated hypersensitiveness and toxicities associated with such combinations must not be disregarded.
These insights should aid the design of new antimicrobial agents able to circumvent resistance through novel interactions at the topoisomerase-DNA interface.
Moreover, DC/NK cell interactions can circumvent the need for CD4+ T cell help during induction of CTLs (Adam et al, 2005), further increasing the appeal of adding LAKs to DCs for enhanced adaptive priming.
Conversely, because of their high replication and propagation rate, viruses have evolved strategies, at least in part driven by molecular interactions, to circumvent host cellular defence and to maintain their control on the cellular machinery.
