Exact(6)
Glioblastomas also nearly universally circumvent cell cycle inhibition through genetic alterations to the RB pathway [2].
The use of genetic markers should eliminate problems with inconsistent labeling and completely circumvent cell viability or functionality issues introduced by dye labeling, even though in vitro cyotkine detection assays suggest that the PKH67 labeling does not obviously affect cellular function (data not shown).
Because Nrf2 improves cellular survival under cytotoxic challenges, cells heavily rely on Nrf2 activation to circumvent cell death.
Survival under conditions preventing normal cell wall formation triggered complex adaptations that incurred a fitness cost, showing the remarkable flexibility of S. aureus to circumvent cell wall damage.
One of such mechanisms, anoikis resistance, plays a pivotal role in enabling metastasis by allowing cancer cells to circumvent cell death induced by lack of attachment.
C2 cells therefore seem to actively respond to KIT inhibition with an alternative quantitative and qualitative gene expression pattern to circumvent cell death.
Similar(54)
In particular, the here- described Nef7/TK VLPs represent a first applicative example opening the way toward new HSV-1 TK/GCV-based cell suicide therapies circumventing cell gene engineering procedures.
These include self-sufficiency in growth signals, insensitivity to growth suppressors, circumventing cell death mechanisms, limitless replicative potential, sustained angiogenesis, and tissue invasion and metastasis [ 1].
This effect of BPA in circumventing cell death was most prominent at 100 nM rapamycin, a concentration at which the apoptotic ratio of drug-treated versus untreated control was >2-fold in the absence of prior BPA exposure.
On the other hand, the process of cancer metastasis demands that cancer cells circumvent such cell death/growth arrest.
Malignant cells must circumvent endogenous cell death pathways to survive and develop into cancers.
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