Thus, the mechanism of action of solanezumab was demonstrated in the phase 2 trial with circumstantial evidence of an effect on Aβ plaque.
Experiments suitable to answer a few circumstantial variations in cause-effect relations are described in the chapter.
The weakest aspect of the circumstantial case is EMF effects on melatonin.
A handful of recent studies in humans and other primates provide circumstantial evidence for social effects on the gut microbiome (Degnan et al., 2012; Kinross and Nicholson, 2012; Yatsunenko et al., 2012; Song et al., 2013).
The evidence for the involvement of the GABAA receptor in GA effects, although circumstantial, is thus quite strong, with a high probability that the gaseous haloalkanes, etomidate and the barbiturates interact with different regions of the α- and β-subunits, while propofol binds to the β-subunit.
Because of circumstantial evidence on the beneficial effects seen when one is intervening with VDRA, it is tempting to speculate that low levels of vitamin D might be a risk marker of both initiation and/or progression of albuminuria in diabetic patients (9).
Annane [ 10] found circumstantial evidence for a clinically deleterious effect of etomidate on adrenal function; septic patients given etomidate received more fluid and vasopressor therapy than those given other induction agents [ 10, 26].
Our study provides circumstantial evidence that after the general effects of (shortened) gestational age and (reduced) fetal growth are accounted for, smoking has little direct impact on neonatal mortality.
The circumstantial case for the hypothesis has three aspects: light effects on melatonin, EMF effects on melatonin, and melatonin effects on breast cancer.
Also, the exact role played by neurotrophins in inflammatory conditions has not been established conclusively, and there is circumstantial evidence supporting both protective and pathologic effects [2], [11], [12].
Circumstantial evidence supporting the view that the effects of BPA are not confined to rapid PSSD responses to estrogen administration is provided by the data for OVX rats.
