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It is often suggested that low concentrations of environmental pollutants are of no concern because, in most circumstances, concentrations are below the No Observed Effect Levels (NOEL); i.e. environmental levels of each individual chemical have been shown to be below the minimum concentrations known to induce a physiological response.
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In such circumstances, CSF concentrations of melarsoprol might be insufficient to eliminate all parasites.
Because, in most circumstances, the concentrations are low, such detailed analysis is normally not justified for routine monitoring".
Under these circumstances the concentration of autoinducer alternates between two states that correspond to a low concentration, when there is no mRNA production, and a high concentration, following the mRNA synthesis.
Under these circumstances, higher concentration of nitrogen source was required to overcome the antagonism.
TGF-β1 is a pleiotropic growth factor with both growth-promoting and growth-suppressive activities depending on circumstances, including concentration, target cell type and context [13] [15], [26], [34], [42], [45], [46].
The method can also be applied, after minor modifications, to circumstances where concentration data for a few molecules are missing.
An extension of this strategy to circumstances where concentration data of some metabolites are missing is also presented.
However, the exact role that hydrogen sulfide plays depends on the specific circumstance, its concentration, and the interplays with other signaling molecules, especially NO and CO.
These findings may be relevant to the clinical efficacy of drugs targeting the receptor, and for pathological circumstances of high concentrations of 5-HT.
Under normal circumstances, relatively low concentrations of ROS are formed in all cells and tissues in oxidative processes and a variety of antioxidative mechanisms serve to control their production [ 6].
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