Hematogenous metastasis of cancer consists of several steps enabling cancer cells to intravasate, to survive in the blood circulation and to adhere to the vessels, eventually extravasating and establishing new metastatic lesions.
Here EMT plays a major role in aiding the tumor cells to migrate out from the primary site, enter into the circulation and adhere to endothelial cells of target organs.
As the infected monocytes travel through the circulation, they may exhibit a greater propensity to adhere to endothelial cells and extravasate.
These adhesive proteins are expressed on the red-cell surface and allow malaria-infected cells to adhere to the tissue of the vascular endothelium [ 3], out of the peripheral circulation and consequently out of the reticuloendothelial system.
In general, antibodies that are chemically or genetically modified to achieve higher, more basic, pI values exhibit a high propensity to adhere to anionic sites of cell surfaces, resulting in increased tissue uptake and fast clearance from circulation.
DCs were allowed to adhere overnight.
Agents have metrics to adhere to.
Be sure to adhere to this.
sFlt-1 is secreted by the placenta into the maternal circulation and adheres to the receptor-binding domains of placental growth factor and vascular endothelial growth factor (VEGF), preventing interaction with endothelial receptors, blocking VEGF-mediated vasodilation and inducing endothelial dysfunction [ 8], considered to be key to the pathogenesis of preeclampsia [ 6].
In fact, in mouse models it has been shown that circulation-derived platelets adhere to the peritoneum surface [ 17].
In vivo, monocytes differentiate into macrophages when leaving the circulation and migrating into specific tissues, a process that is mimicked in vitro by allowing blood monocytes to adhere and differentiate on tissue-culture treated plastic.
