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Pharmacokinetics of FV-17B in mice demonstrated distinctly superior systemic circulation time for TQ in plasma.
Greater understanding of pharmacokinetics, biodistribution, and disposition of lipid drug particles facilitated particle surface hydration technology (with polyethylene glycol) to reduce rapid clearance and provide sufficient blood circulation time for drug to reach target tissues and cells.
Another advantage of nanoscale system is that they are capable of effectively overcoming clearance by the kidney and thereby provide good blood circulation time for the drugs they carry.
The PK experiment indicated a prolonged blood circulation time for the combinatory PLGA NPs.
Since the drug is mainly released intracellularly and the circulation time for the dendrimer is low, most of the dendrimer drug conjugate that is not taken up by cells is excreted intact by the kidneys.
The therapeutic protein delivery system (TPDS) offers longer circulation time for the therapeutic protein in the patient's body and enhanced pharmacokinetics (PK) and pharmacodynamics (PD) properties and is now extremely valuable from the commercial point of view [ 23].
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Both netLibrary and ED imitate the circulation function of library systems, allowing libraries to set short circulation times for reference books and longer times for nonfiction and fiction.
By mimicking elasticity ranges of biological tissues (∼0.5 kPa for soft tissue (e.g., brain), ∼10 kPa for moderate tissue (e.g., muscle), and >30 kPa for hard tissue (e.g., bone)) in a biomaterial, one can influence cellular response to that material, which can then prolong circulation times for drug delivery vehicles or facilitate cell proliferation on tissue scaffolds.
On the other hand, it has been reported that CD couldn't influence the pharmacokinetics of drugs [39, 40], while much more drug would be accumulated in the solid tumor region due to delay of the circulation time of drugs for polymeric micelles [22, 27, 39, 40].
We obtained independent evidence for the estimated circulation time of asexual parasites by directly estimating asexual parasite stage for each field sample, using a previously developed linear regression model [ 29].
The quantitative evaluations in this study provide a useful guideline to tailor the in vivo stability and the blood circulation time of 3-helix micelles for different biological applications.
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CEO of Professional Science Editing for Scientists @ prosciediting.com