Exact(2)
Liposomes with enhanced drug delivery to disease locations, by ability of long circulation residence times, are now achieving clinical acceptance.
Moreover, the phospholipid surface can be adapted to various surface modifications already established for liposomes to control the targeting or enhance circulation residence time [20 22].
Similar(58)
A dual circulating fluidized bed (DCFB) system has been designed with the important characteristics of high solid circulation, very low residence times and a high power to solid inventory ratio.
Injection of monocytes/macrophages into the systemic circulation resulted in residence in the liver and lungs as well as transport to the brain metastasis.
Since many environmental toxicants undergo phase II metabolism [see Supplemental Material, Table 1 (http://dx.doi.org/10.1289/ehp.1104204)], those that are excreted in the bile may be further metabolized by the enzymes of gut microbiota, including glucuronidases, leading to enterohepatic circulation and increased residence time in the body (Humblot et al. 2007).
Several monkey species (i.e., Cebus olivaceus and Alouatta seniculus) and competent MAYV vectors (i.e., Haemagogus mosquitoes) are present within this village (33, 34 ), which suggests enzootic circulation near human residences and work locations, possibly enhanced by encroachment into forests by local residents.
High solids circulation, very low solids residence time and low solids inventory are observed during operation.
For high internal circulation rates the solids residence time distribution of the fuel reactor is dominated by the bypass effect.
Inside, wide halls and generous door openings allow easy circulation through the 3,500-square-foot 3,500-square-foot 3,500-square-foote and a half baths.
Comparison of residence and circulation time distributions in three zones defined inside the bioreactor shows that the inhomogeneous CTMC model predicts with an excellent accuracy the particle trajectories inside the bioreactor.
Reactor parameters that we have investigated in detail include the oxidizer and chlorinator temperatures, the catalyst circulation rate and its residence time in each fluidized bed reactor, the HCl/O2 ratio in the oxidizer feed, and the fluid velocities in both reactors.
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