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So, are there alternatives to the glymphatic circulation proposal?
The two alternative hypotheses indicated and the glymphatic circulation proposal are not mutually exclusive and furthermore there may be other scenarios.
Thus the observation that AQP4 knock-out reduces movement into the parenchyma without reducing convection in the periarterial space presents the glymphatic circulation proposal with a substantial challenge.
The observed sequence, near arteries, near microvessels then near veins, is a major pillar of the glymphatic circulation proposal: fluid flow inwards along the arteries, then through the interstitium and thence outwards along the veins [ 143].
In either of these alternatives, convection assists movement into and out of the cortex without necessarily producing the net flow of fluid into the cortex as required by the glymphatic circulation proposal.
The glymphatic circulation proposal has been used to interpret experimental results on the effects of sleep and anaesthesia on perivascular fluid flow and interstitial volume in the parenchyma [ 143, 201].
Similar(49)
The periodical started its circulation after a proposal by Adamantios Korais, a leading figure of the modern Greek Enlightenment, who had stressed the need of a printed medium, written in vernacular Greek.
Since the citizen initiative process began in 1912, only 25% of the more than 1,800 ballot proposals cleared for circulation (allowing proponents to circulate petitions and gather signatures) have qualified for the ballot.
In 1983, Fred Fielding, the White House counsel, asked Roberts to evaluate a proposal then in circulation to create a kind of super appeals court to assist the Supreme Court with its ostensibly pressing workload.
Joe Mathews, a fellow at the Center for Social Cohesion at Arizona State University, argued on California politics website Fox&Hounds that forcing the attorney general to allow the circulation of such an absurd proposal attacks the integrity of the initiative process.
Proposals already in circulation suggest the junta is likely to plump for a lower house elected by proportional representation and by a nominated senate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com