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Then, as a result of tissue damage, disruption of the mucosal barrier and access to the systemic circulation of toxic entities occurs.
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The hypothesis exists that part of pathogenesis of scleroderma is circulation of an endothelial toxic agent, loss of circulating endothelial precursors or some other less specified dysregulation of the angiogenic pathway[48], [49].
The micelles exhibited a controlled drug release for up to 96 h which can minimize the non-specific systemic spread of toxic drugs during circulation while maximizing the efficiency of tumor-targeted drug delivery.
It is hard to say for sure how much thésards share their supervisors' aspirations for the street-level extension of drug and food quality regulation and the circulation of information about exposure to toxic chemicals.
Consequently, a third blood supply to these areas may help spare them the adverse effects of toxic agents entering through the portal circulation.
The BBB protects the brain from the peripheral circulation and toxic substances and restricts the transport of many therapeutically important drugs from the blood into the brain.
Similarly, hypoxia due to lung damage by SSc may cause accumulation of toxic metabolites, e.g., lactate that are normally removed by circulation.
It is also possible that a small fraction of toxic components is carried via various translocation mechanisms into the circulation on UFPs (Mühlfeld et al. 2008).
Out of toxic contagion.
Presence of toxic gases.
They're mounds of toxic stone.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com