The effects of polymer viscosity, brine salinity and re-circulation of polymer effluent on degradation were investigated.
Moreover, the presence of alkyl moieties at the chain extremity influenced circulation time and tissue distribution of polymer chains, hypothetically through formation of micellar structures.
Thus water-soluble cyclic comb polymers join a growing list of polymer topologies that show greatly extended circulation times compared to their linear counterparts and provide alternative polymer architecture for use as drug carriers.
The mutually conflicting surface charge requirements for nanoparticles to have long circulation and good cell affinity have made the development of polymer nanoparticles for controlled drug delivery fall into a dilemma.
Reversible or irreversible covalent attachment of polymer to small molecule non-peptide drugs can result in reduced metabolism, increased circulation time, improved activity and reduced toxicity.
Ye and colleagues have also examined the effect of varying molecular weights of polymer, finding that conjugates with higher molecular weights (87 kDa) exhibited more prolonged blood circulation and increased tumor accumulation over lower molecular weight conjugates (28 kDa).
A finite amount of polymer residue may have been left in the formation, as a consequence of the lost circulation material during drilling.
In order to prolong the circulation time of 5-FU and increase its efficacy, numerous researchers have attempted to modify its delivery by use of polymer conjugates or by incorporation of 5-FU into particulate carriers [ 19- 23].
It is her favorite material, proving that you can take the girl out of polymer science, but you can't take the polymer science out of the girl.
His father was an owner of Polymer Design, a manufacturer of plastics in Rockland, Mass.
A leading scientist and chemist in the fields of polymer and biochemical science and nano technology.
