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Secondly, specific documentation of DENV serotypes that firmly establish the circulation of different viral variants was not performed due to logistic and financial constraints.
The continuous circulation of different serotypes, including live vaccine strains, in this geographic region provides the conditions of genetic reassortment, and the generation of novel strains, potentially with altered biological properties.
To evaluate and compare the alternative vaccination strategies, we analyzed the time series representing the circulation of different influenza virus strains by subtype and city, relative to the time period when the influenza vaccine would effectively protect the target population.
Nevertheless, a wide distribution of plasma levels of exosomes was detected by Exotest in all disease stages, suggesting that the variability in the amount of exosomes present in peripheral circulation of different patients may reflect diverse levels of tumor aggressiveness and may become a novel independent prognostic factor for melanoma.
In the Americas, bats maintain the circulation of different lineages of rabies virus (RABV, genotype 1) (1 ).
Sequences for g3 subtypes from Italy and Spain exhibited <85% nucleotide identity, suggesting circulation of different strains in these countries.
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Despite annual co-circulation of different subtypes of seasonal influenza, co-infections between different viruses are rarely detected.
Likewise, conclusive evidence for the co-circulation of different CPXV strains within the same geographic region has rarely been provided but was rather assumed [8], [16].
The co-circulation of different genotypes at the same time and other introductions of new viruses in relation with the worldwide intensification of animal movements, may contribute in the future to dramatically increase the complexity of the situation.
Although some clusters of similar genotypes in a limited period of time were observed, co-circulation of different genotypes and HRV species and subspecies, and co-infections with two HRV species were observed.
Increasing endemicity and co-circulation of different serotypes is therefore necessary for the increase in incidence of DHF.
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