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However, the drug delivered onto the sclera subjects to vigorous clearance by episcleral and choroidal circulation; in addition, the penetration from episclera to retina needs to overcome counter-directional ocular fluid current driven by intraocular pressure (IOP) as well as unfavorable drug disposition exerted by drug transporters before the drug reach retina.
A laboratory that, according to some sources, produced 90percentt of the LSD in circulation, in addition to unknown quantities of MDMA, ALD-52, ergot wine, and quite possibly LSZ... but I'll get to that later.
A total of 465,814,455 Franklin half dollars were struck for circulation; in addition, 15,886,955 were struck in proof.
Previous studies claim the existence of a gradient of species richness from the northwest to the southeast Mediterranean [e.g., [90],[251],[294]–[297]], in agreement with differences in key environmental variables, such as latitude, salinity, temperature, and water circulation, in addition to the distance from the Strait of Gibraltar.
Cholesterol is constantly taken up by retina via LDL receptors from the circulation in addition to endogenous cholesterol synthesis.
Once the particles have reached pulmonary interstitial sites, uptake into the blood circulation, in addition to lymphatic pathways, can occur; again, this pathway is dependent on particle size, favoring NSPs.
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Similarly, the use of silicate drilling fluids offers the advantages of prevention of bit-balling, differential sticking, and lost circulation and, in addition, promotes corrosion inhibition.
Like for many nanodrugs, PEG can be used as an attachment biomaterial on the surface of metallic nanoparticles to increase stability and circulation time, in addition to other targeting agents [81].
An altered microclimate favoring TBE circulation (1 ), in addition to introduction of the virus, could also explain the recent emergence of TBE in Simo.
FXR α plays important roles in regulation of BA synthesis, regulation of the enterohepatic circulation of BAs, in addition to regulation of glucose, lipoprotein, lipid metabolism, inflammation, and tumor suppression.
In addition, circulation time of optimized PL was significantly prolonged by the modification onto NPs.
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