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The effects of extracorporeal circulation are difficult to assess.
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Detecting impaired myocardial relaxation in the hyperdynamic circulation is difficult due to the strict cut-off values.
Of particular concern is the case of extravasation, where measurement of the actual radioactivity of FDG injected into the circulation is difficult to determine because FDG could be absorbed by subcutaneous tissue or vascular tissue.
However, the circulation was difficult to locate, and as such its exact motion was uncertain.
After classification, the center of circulation was difficult to locate due to the re-organization of convection.
Upon being classified a tropical depression, the NHC noted that the center of circulation was difficult to locate and the mid-level circulation was displaced from the low-level circulation.
However, haemodynamic studies in an unstable and deteriorating circulation such as cardiogenic shock are difficult to conduct and the data equally hard to interpret when large animal variations occur.
Since much of the fine-wine business is conducted in off-the-books "gray market" exchanges between buyers and resellers with no direct link to the château, ascertaining who actually put a particular bottle of wine into circulation can be difficult.
And, with so many devices designed to be tiny and unobtrusive, pulling them from circulation could be difficult if they are captured in a botnet or go rogue.
Upon being classified, the disturbance had a broad circulation that was difficult to locate, with moderate convection in its eastern periphery.
Sarah's broad circulation center was difficult to locate until it began moving northeast east of Luzon on August 2, when it intensified to its peak intensity.
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