Twist1 can induce EMT to facilitate breast cancer cell intravasation into the circulation and the subsequent dissemination of these cells into the lungs.
Both outcomes are likely to be beneficial to the survival of the cancer cell in the systemic circulation and at sites of dissemination.
On the other hand, autophagy induces anoikis resistance for survival and dissemination in the circulation of cancer cells.
As the in vitro data showed that reduced plakoglobin expression increased the prometastatic phenotype of MCF7 and T47D cells, we next investigated the effects of reduced plakoglobin on tumor cell growth and dissemination into the circulation in vivo.
The basic helix-loop-helix (bHLH) transcription factor TWIST1 was previously demonstrated to be a potent promoter of cancer cell dissemination into circulation and metastasis [ 2- 7], providing an ideal target for investigation and a promising therapeutic target for intervention.
We show that fibrinogen binding by recombinant LigB inhibits fibrin formation, which could aid leptospiral entry into the circulation, dissemination, and further infection by impairing healing.
Cancer metastasis is the main cause of cancer-related death, and dissemination of tumor cells through the blood circulation is an important intermediate step that also exemplifies the switch from localized to systemic disease.
This rules out the possibility that the targeted ablation of FKN could non-specifically affect cell dissemination through blood circulation and reinforces the specificity of the CX3CR1-FKN pair in regulating the migration of cancer cell to the skeleton.
Either scenario, or a combination, is conceivable, since a cell that has completed the metastatic cascade has proven to be capable of dissemination into the circulation and of formation of a metastasis.
Methods of translational research, implementation & dissemination, and its theoretical references, concepts of knowledge circulation, and criteria for assessment of these processes are established subjects of implementation and dissemination science.
