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Developing protein therapeutics has posed challenges due to short circulating times and toxicities.
These activatable contrast agents provide benefits of longer circulating times and smaller sizes relative to conventional microbubble contrast agents.
Prophylactic therapy will be facilitated via the development and introduction of clotting factors with prolonged circulating times.
Single walled carbon nanotubes (SWNTs) are emerging as promising delivery vehicles for cancer diagnostics and chemotherapies due to their unique properties, including, remarkable cell membrane penetrability, high drug-carrying capacities, pH-dependent therapeutic unloading, prolonged circulating times and intrinsic fluorescent, photothermal, photoacoustic and Raman properties.
Besides their size, intratumoural accumulation of macromolecules is further enhanced by carrier systems displaying reduced release rates and long circulating times (Papahadjopoulos et al, 1991; Yuan et al, 1994).
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The average circulating time prior to tripping out of hole was 1 ¼ h.
In addition, the acceptable small size of nanoparticle can increase blood circulating time of nanoparticles and cellular uptake.
Then, the calculation can provide a forecast of gas kick location versus circulating time for circulating kick out of hole operation.
A pharmacokinetics study showed that SN-38 micelle formulations had a longer circulating time in blood than irinotecan.
Using ultrasound contrast, it has also been demonstrated that not only the size, but also the surface architecture of the bubble influences the circulating time [33].
At the physiological pH 7.4 in the bloodstream, PEG-PLL DA) could extend the circulating time by shielding the PEG-PLL DA couldextendp53 complexes.
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