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However, estrogenic compounds may contribute in a cumulative way to the circulating estrogen burden.
Following CEE administration, E1 is the principal circulating estrogen.
Animal studies suggest that increased circulating estrogen and progesterone, and activation of the endorphin system cause prenancy-induced antinociceptive effects.
The researchers propose that fat tissue becomes the primary estrogen source after menopause, and that increased levels of circulating estrogen explain the increased risk.
Women with PCOS have many components of the metabolic syndrome (a risk factor for heart disease) along with erratic levels of circulating estrogen.
This circumstance is usually attributed to a deficiency in circulating estrogen levels although the underlying mechanism remains elusive.
Phytoestrogens are bioactive plant chemicals found in soy, which have a similarity in structure to natural estradiol (the most abundant circulating estrogen).
Some of these therapies can induce premature menopause or are specifically designed to suppress ovarian function and reduce circulating estrogen levels.
Menopause marks the start of a new phase in a woman's life that is associated with a decrease in circulating estrogen levels.
When circulating estrogen levels decline as a natural consequence of menopause and aging in women, there is an increased incidence of deficits in working memory.
PURPOSE: Circulating estrogen levels are relevant in glaucoma phenotypic traits.
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