Exact(3)
A limitation of current vaccines is that the major vaccine targets, the antigenic regions of HA, are highly susceptible to continuous mutation in circulating epidemic virus strains [1], [2].
In a molecular epidemiologic study, we showed that HIV was introduced at least 9 times into Greenland, and that one of these introductions has given rise to a circulating epidemic that has included 76% of all infected persons (3 ).
Apart from their limited efficacy in the elderly, a major drawback of current vaccines is that the principal vaccine targets, most notably the distal region of HA, are subject to continuous alteration in circulating epidemic virus strains (2, 3).
Similar(57)
Both subgroups circulate during epidemic seasons with an alternate predominance every one or two years [ 28].
Considering that all 7 strains were isolated during the 2000 Marseille epidemic during which the E30 and E13 serotypes were particularly prominent, this genetic similarity could explain the emergence of E13 as an epidemic serotype by a recombination between circulating E13 and epidemic E30 strains.
The same strain (Vibrio Cholera O1 El Tor-Ogawa) was circulating during that epidemic and most natural immunity acquired during 2005 had probably vanished during the three-year inter-epidemic period.
Although the number of strains typed by MLST in our study was relatively low due to logistic constraints, and this could introduce a bias, we believe that our MLST results provide a reasonably representative picture of the different ST circulating during the epidemic seasons.
The sequences indicate recent movement of RVFV and support the need for surveillance to recognize when and where RVFV circulates between epidemics, which can make data from prediction tools easier to interpret and preventive measures easier to direct toward high-risk areas.
Sequences of DENV-2 isolates from the 1998 epidemic grouped with sequences of DENV-2 isolates from the 1990 epidemic (data not shown) suggesting that viruses circulating during these 2 epidemic periods belong to the same lineage of the DENV-2 strain originally found in the state of Rio de Janeiro.
During the 1996 and 1998 epidemic, multiple clades co-circulated during the epidemic peak, although one was still dominant.
The early 1990s were also the height of the AIDS crisis in this country (one of Ms. Smith's younger twin sisters died of AIDS in the late 1980s), and various ideas about the human body, particularly in response to the new epidemic, were circulating in and around the art world.
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