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These technologies are starting to yield information on connectivity and dynamics in cellular circuits at unprecedented resolution, and bring us closer to system-level understanding of physiology and diseases of complex mammalian systems.
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Ultimately, we envision that crisprTFs will enable the regulation and perturbation of natural transcriptional networks as well as the construction of complex synthetic circuits at an unprecedented speed and scale.
In 1962, the British physicist Brian David Josephson predicted that electricity would flow at unprecedented speeds through a circuit composed of two superconductors separated by a "weak link" material.
The two Breeders' Cups staged on a synthetic circuit at Santa Anita yielded unprecedented success for the raiders, with five winners in 2008 and six in 2009.
Thereafter, the economy expanded at unprecedented rates.
Honeybees have been dying at unprecedented rates.
Ecosystems around the world are changing at unprecedented rates.
Applications for slots and licences are running at unprecedented levels.
On drugs, cross-border co-operation is at unprecedented levels.
And minority candidates hold office at unprecedented levels.
The economy grew at unprecedented speed during the 17th century.
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