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In the event of prolonged support, the influence of regional anticoagulation on CO2 dialysis circuit life is worth investigating.
Citrate versus heparin Randomized studies show that citrate is better tolerated, confers less bleeding, longer circuit life, a higher delivered dose and reduces the costs of CRRT [169].
This article will focus attention on the components and design of the CRRT circuit, identifying strategies in the literature which may promote circuit life.
Therefore, improving circuit life is clinically relevant.
The mean circuit life was 28.9 hours (P > 0.05).
One major intervention to influence circuit life is anticoagulation.
Median circuit life was 24.5 h (IQR 12-37 h).
There was no significant difference in mean circuit life between heparin given via circuit (n = 169 circuits; mean circuit life 19.8 hours) and epoprostenol alone (n = 119 circuits; mean circuit life 20.9 hours).
Dosing of heparin is "individualised" depending on the patient's risk of bleeding and previous circuit life.
Indeed, a shorter circuit life may result in underdosing of CRRT.
The difference in circuit life span was not significantly different between the two groups.
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