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Thus, a lower CIPHER score represents a higher phenotypic divergence.
Correlation between phenotypic similarity, as determined by CIPHER score and the measures of centrality was determined using Spearman's rank correlation.
We retrieved CIPHER score for all diseases associated with the same gene and recorded the lowest score for each shared gene.
We classified the shared disease genes into genes associated with phenotypically similar diseases (phenosim genes) and those that are associated with phenotypically divergent diseases (phenodiv genes) based on CIPHER score [ 13].
Using the median CIPHER score (0.33) of the entire dataset as cut-off, we then categorized these genes into genes associated with phenotypically similar diseases (Phenosim genes with CIPHER scores ≥0.33; n = 238) and genes associated with phenotypically divergent diseases (Phenodiv genes with CIPHER scores < 0.33; n = 234).
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The CIPHER method scores the candidate genes using a regression model of phenotype similarity and gene closeness in a network [ 16].
Another of the ensemble's composer-performers, Kate Soper, sang her own "cipher," an exotic score in which her vocal settings of text fragments from Wittgenstein, Freud, Jenny Holzer, Michael Drayton and Sara Teasdale closely matched, in timbre and gesture, a brash violin line played energetically by Joshua Modney.
CIPHER provides a similarity score of phenotypes for diseases in MorbidMap, based on their OMIM descriptions using Medical Subject Headings (MeSH) terms.
Cipher: 1.
German ADFGVX cipher.
Carlebach remains a cipher.
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