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To further examine whether mast cells are involved in the pathogenesis of CIM, we next analyzed the incidence and severity of CIM in W/Wv mice with or without the reconstitution of mast cells.
Systemic corticosteroid hormone treatment, post-synaptic neuromuscular blockade and sepsis have all been suggested to be important factors triggering CIM [ 33, 37], although mechanically ventilated and sedated ICU patients have been reported with CIM in the absence of exposure to these triggering agents [ 38- 41].
CIM in combination with CIP is associated with a more severe weakness and longer ICU length of stay than CIM alone [ 29].
Anna the housemaid - then in her early 20s - volunteered early on, and together with the family governess, Sophie Reuter, joined the CIM in 1884.
The high expression level of OsLEA1 is also detected at CIM in ANT39 (Figure 5c).
QTL analysis was performed using single point analysis (SPA) and composite interval mapping (CIM) in Q-gene (ver. 4.3.10).
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The second sample consisted of a total of 306 8- to 10-year-old children and their parents who participated in the CIM study in 1993 94 or in 2011.
In our previous study, we observed that the telodendrimer could form core-inversed micelles (CIMs) in some apolar solvents, such as toluene and ethyl acetate.
We also show that the numbers of macrophages in the affected muscle in CIM are reduced in W/Wv mice.
This is consistent with previous observations in patients with CIM and in experimental ICU models [ 5, 6, 8, 35, 36].
The number of CD8+ T cells and macrophages in the skeletal muscles of CIM decreased in W/Wv mice compared with WT mice.
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