Sentence examples for cic in from inspiring English sources

To comprehensively understand the function of CIC in maintenance of peripheral immune tolerance, functions of CIC in other types of immune cell, such as DCs and B cells, need to be further determined.

Our study finds previously unrecognised functions of CIC in regulation of T-cell activation and GC responses and suggests CIC as a key transcription factor in the suppression of autoimmunity.

To directly address the function of CIC in development and function of FOXP3+ Treg cells, we generated FOXP3+ Treg cell-specific Cic null (Cicf/fFoxp3-YFP-Cre) mice by crossing Cicf/f mice with Foxp3-YFP-Cre mice51.

In this study, we examined a previously unrecognised function of CIC in the immune system.

Because several abnormalities in T cells were observed in Cicf/fVav1-Cre mice, we next examined CIC in T cells.

Taken together, these findings demonstrate that the spontaneous inductions of T-cell activation, GC response and systemic autoimmunity were due to loss of CIC in T cells.

Ciclesonide is a prodrug that is converted to an active metabolite, desisobutyryl-ciclesonide (des-CIC), in pulmonary airways by endogenous esterases.

These conjugates in turn slowly re-release des-CIC in pulmonary tissue with the overall effect being enhanced lung retention of the active metabolite.

Despite the increase of IgG2a-CIC in Hg-treated wt mice (Figure 2) neither renal mesangial nor splenic vessel wall deposits contained IgG2a (data not shown).

The Nave et al study shows that the combined deposition of CIC and des-CIC in the oropharynx was less than half (47%) of that of BUD.

Titer of LDL-CIC in blood serum significantly correlates with progression of IMT and has the highest diagnostic value among other measured serum lipid parameters.