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The therapeutic effect of anti-TNF-α in CIA was later shown to relate directly to the stage of CIA development at the time treatment was initiated, with maximum effect achieved when treatment was started just after disease onset.
DCB was also responsible for generating CIA development in selectin deficient mice, and offered valuable advice.
Two of the loci promoted disease and the third locus was protected against CIA development.
Overall, antibody titers in DR4-transgenic mice showed a tendency for correlation with CIA development.
We also considered the possibility that CXCL12 favours CIA development by somehow affecting systemic cytokine production.
This specificity dominated during all stages of CIA development in both experimental strains.
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Our results indicate that epitope spreading in CIA includes development of autoantibody responses targeting citrullinated epitopes at the pre-boost (pre-arthritis) timepoint, and that there is significant expansion of autoantibody responses to target a panel of citrullinated polypeptides in both acute and chronic arthritis.
Given that the Cia proteins contribute to the development of C. jejuni-mediated enteritis, additional work is warranted to further dissect the functions of these proteins.
This is also in agreement with our previous results indicating that the Cia proteins contribute to the development of disease in piglets [ 14].
Cia Sohlman, responsible for sustainable materials strategy and development at H&M. Christian Wieth, senior manager in textile and leather, Novozymes.
injection of type II collagen into CIA-immunized plasminogen-/ mice, which are normally resistant to arthritis development [ 5], led to arthritis in the injected joint.
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