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In combination with other PK/PD data, it is suggested that therapeutic targets for CI therapy should be a steady-state concentration (Css) that is at least 4 x MIC [33].
Preclinical data do not evaluate the different methods of 5-FU administration such as protracted CI therapy vs bolus therapy.
In combination with other PK/PD data, it is suggested that therapeutic targets for CI therapy should be a steady-state concentration (Css) that is at least 4 x MIC [ 33].
Thus there is moderate evidence for the effectiveness of CI therapy on functional hand use.
The median WHO score for haematological toxicity was 4 for bolus therapy and 3 for CI therapy (P = 0.0007).
The overall median survival was 25 weeks for patients in the bolus arm and 30 weeks for the CI therapy (P = 0.45).
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Taken together, our results shed light on the rational design of CuS nanomaterials to minimize toxicity, thus providing a useful guideline in selecting CuS as the photothermal agent for cancer therapy.
Moreover, in vivo combination therapy study revealed that Ce6-CuS-TSL inhibited tumor growth to a great extent without evident side effect under the laser irradiation.
Guo et al. have developed chitosan-coated hollow CuS nanoparticles that assemble the cytosine-guanine oligodeoxy nucleotides for photothermal therapy in a mouse breast cancer model [32].
In conclusion the CuS-Ce6 NPs act as multimodal agent for photo based imaging and therapy.
Comparing with CuS nanoparticles, surface plasmon-enhanced Ag/CuS nanocomposites have a higher efficiency for the photothermal therapy.
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