Drug interaction was assessed using the combinatory index, where CI < 1, CI = 1 and CI > 1 indicate synergistic, additive and antagonistic effects.
CI < 1, CI =1, and CI > 1 indicate synergism, additivity, and antagonism, respectively.
CI >1 denotes antagonism, CI = 1 denotes additivity, and CI < 1 denotes synergism.
A combination is considered to be synergistic if CI <1, additive if CI = 1, and antagonistic if CI > 1.
According to the software, CI ≤1 indicates synergism, CI = 1 indicates an additive effect, and CI ≤1 indicates drug antagonism.
An average CI < 1 indicates synergism, CI > 1 indicates antagonism and an average CI = 1 indicates additivity [20].
Synergy is determined for CI < 1, additivity for CI = 1 and antagonism for CI > 1 [36].
In this method, a CI <1 represents synergism, whereas a CI = 1 represents an additive effect and a CI >1 represents antagonism.
The combination index (CI) was generated by Compusyn software, where CI < 1, CI = 1, and CI > 1 indicated synergism, additive effect, and antagonism, respectively.
A CI < 1, CI = 1, or CI > 1 indicates synergistic, additive, or antagonistic effects, respectively.
