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The reason for creating reliable overlaps is to avoid creating misassemblies at the early stages of the assembly when the contiguous chunks of sequence (contigs) are built using only overlap information.
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The software helped break the mixture of DNA into chunks of sequences, and then match those chunks to assemble the complete genome for a specific organism.
We sent smaller chunks of sequences to the server to optimize the resource usage.
For the genomes that are not assembled into chromosomes (e.g., the Fugu genome), we integrated the scaffold sequences into several large chunks of sequences before applying PseudoPipe.
(2007) argued that the sequence-specific learning tapped by the SRT task is likely also to be involved in extraction of higher-order relationships such as graded probabilistic relationships or chunks of sequences (Cleeremans & McClelland, 1991; Curran & Keele, 1993; Stadler, 1995), but it would be of interest to look explicitly at this issue in future studies of SLI.
This "wouldn't have been possible three years ago," notes Reich, because the researchers needed large, adjoining chunks of genome sequence to use as a starting point.
They looked for everything from easy-to-find differences in single bases to much more obscure variations in chunks of DNA sequence that had been inserted or deleted from chromosomes.
In a separate paper4, other members of the PsychENCODE Consortium focused on the potential role that gains or losses of large chunks of DNA sequences called copy number variations (CNVs) might have in neuropsychiatric disease.
At the time this work was performed this was the largest contiguous chunk of finished sequence that was available to us.
Finally, large chunks of annotated DNA sequence are submitted to GenBank.
Adam Boulton at the Sky blog The ex-PM wrote this autobiography himself, taking time off over the past three years (often in the Caribbean) to work on chunks of it out of sequence.
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