"Doggystyle" was his first album by chronological measures, but Snoop was such an instinctive and studied rapper that he never sounded green or shaky.
Compared to chronological measures (age), screening with established biomarkers of behavioral aging, may therefore improve the resolution also of studies that are concerned with identifying the molecular mechanisms involved in brain aging.
Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain).
A Spearman correlation analysis found highly significant correlations between expression value and mosquito chronological age (measured in days post pupal emergence) for all seven genes (Table 2), with R2 value ranging from 0.5 (P<0.01) to 0.93 (P<0.93).
Analysis of the simple regression, when we took the sum of the seven teeth as the predictor and chronological age (measured in months) as dependent variable, was found to be statistically significant (see Table 2).
In unicellular fungi, researchers use two different cellular situations in order to study the mechanisms of aging: replicative aging refers to the number of descendents that a cell can generate before its death, whereas chronological lifespan measures the viability of cultures at the stationary phase of the growth curve.
We call this hexad relationship a demographic time framework because it is based on the events of birth and death in calendar time, entailing six time measures: chronological age (A), period (P), birth cohort (C), time to death (T), death cohort (D), and individual lifespan (L).
Identification of genes associated with aging in An. gambiae provide an alternative set of tools for understanding mosquito senescence generally, and measuring chronological age sensitively [5].
Yeast chronological lifespan was measured as previously described (Fabrizio and Longo, 2003).
While deletion or knockdown of ACS1 or ACS2, respectively, barely affected yeast survival during chronological aging as measured by clonogenic assays, deletion of either ACH1 or MPC1 dramatically reduced lifespan.
