Sentence examples for chronological lifespan from inspiring English sources

Reducing TORC1 signaling by rapamycin couples respiration and ROS during growth, which extends chronological lifespan in yeast (Pan et al., 2011).

Importantly, RTG/AMPK activation reprograms energy metabolism to increase the supply of acetyl-CoA to lysine acetyltransferases and extend the chronological lifespan of ρ0 cells.

In contrast, constitutive activation of Ras2 by the RAS2val19 mutation shortens chronological lifespan [18].

These findings indicate that replication stress is an important determinant of chronological lifespan in budding yeast.

Abrogation of this negative regulatory mechanism in sch9Δ cells extends chronological lifespan [5].

To assess chronological lifespan, cells from exponentially proliferating cultures were inoculated into 50 mls.

In addition, inhibition of TOR have been shown to extend chronological lifespan of budding yeast [45].

Although the basis for the decreased chronological lifespan in SC medium is not clear, nutrient-depleted cells cultured in this medium exhibit a higher metabolic rate, which correlates with shorter chronological lifespan [18].

Although deletion of CLN3 extended the chronological lifespan of polyploid cells, it did not extend the chronological lifespan of haploid cells in this prior study or in our experiments (not shown).

This is also consistent with the possibility that caloric restriction can extend chronological lifespan by downregulating Cln3.

Similar to deletion of SCH9, deletion of RAS2 extends the chronological lifespan of nutrient-depleted budding yeast cells [18].