Aging is, however, a complex, multifactorial process with a highly variable impact on health status, which makes it difficult to determine to what extent chronological age contributes to age-associated changes in the immune system.
For example, L1PA, the youngest L1 subfamily, demonstrated >30% average methylation, whereas the older L1PB and L1MA-ME subfamilies were demethylated to a greater extent in chronological order of evolutionary ages.
To a large extent, the chronological age of the plant, percentage humidity of the harvested material, situation and time of harvest, solvent used and the method of extraction were possible sources of variation for the bioactivity of the extracts [ 50- 52].
The investigation of the distribution of articles for each journal across time provided a chronological pattern regarding to what extent a specific journal followed a similar tendency towards argumentation as the general pattern.
This indicates that the majority of bivariate associations could be explained by intrinsic ageing (chronological age) to a large extent.
AGEs are derived from both exogenous and endogenous sources, and the rate at which AGEs accumulate in the body is dependent to a large extent on the chronological age, lifestyle and metabolic health of an individual.
However, our review of the literature found surprisingly few high quality chronological constraints on changing glacier extents on these timescales in the maritime and sub Antarctic sector.
As we are uncertain to what extent this reflects the chronological age of the patient, or that of the cell of origin in childhood leukaemia, we have started to investigate this more comprehensively.
To some extent, this is a matter of chronological happenstance: Kazan was born in 1909, Mr. Lumet in 1924 and Mr. Scorsese in 1942.
As reported previously [41], adding sorbitol to medium extended the chronological lifespan of BY4741 cells to a similar extent compared to caloric restriction (Fig. 2K).
Of course, some chronological sequences could not be probed to the same extent with all interviewees.
