This would make biological sense because reversible changes in species-specific developmental dynamics during chronological evolution required flexible and adjustable instruments allowing allocating cellular resources, such as energy, for growth and reproduction.
Note that, in this scenario, contact patterns are regenerated at the beginning of each realization, and while the contact likelihood between pairs of agents are held invariant between realizations, the network dynamics and chronological order of the contacts are not preserved.
In our study, we focused on the dynamics of biological processes during chronological aging and the comparison between chronological and pathology-related aging.
Besides focusing on the dynamics of processes during chronological aging, we additionally scored a range of age-related pathologies (n=18, of which some are possibly novel as an aging-marker, Table 1) in a systematic fashion over time in these five organs to address pathology-related aging.
Firstly, using the intercurrent gene expression profiles from the six time points, we were able to follow the dynamics of biological processes during chronological aging.
Furthermore, in yeast grown under CR on 0.2% glucose and recovered at different periods of chronological lifespan, LCA altered the age-related dynamics of changes in the cellular level of ATP, which in yeast limited in calorie supply is known to be produced mainly in mitochondria [ 83].
Regarding this last point, for each monument, discrimination of different "melt batches" of lead through trace element analysis was able to highlight unprecedented chronological sequences, thus greatly improving our understanding of the building dynamics.
These processes have previously been correlated to chronological aging by others [ 12, 53- 67], but interpreting the dynamics of biological functions throughout the lifespan in multiple tissues has been proved difficult so far.
To test the validity of our hypothesis, we assessed the age-related dynamics of changes in several vital mitochondrial functions during chronological aging of WT and atg32Δ yeast cells.
Diverse methodological approaches have been used to integrate paleoclimatic, chronological, and archaeological datasets [36], [37] in efforts to understand human population dynamics during this period, and discussions have also focused on limitations of radiocarbon dating [24], [38] [41].
