On the other hand, if the system has matrix elements such that we are in a hawk-dove quadrant the cancer while not "cured" (which is the prisoner's dilemma end-point) but rather the cancer cells are in a stable equilibrium: chronically present but not life threatening, a region of permanent dormancy.
Indeed, some SASP factors, when chronically present, can disrupt tissue structure and differentiation [24], and others can promote malignant phenotypes in nearby premalignant cells [15], [25], [26], [27].
It is known that FFA are positive modulators of insulin secretion in short-time perspective but become toxic to β-cells when chronically present in elevated levels (lipotoxicity) [1], [2], [3], [8], [9], [10].
However, when senescent cells are chronically present, which appears to be the case as mammalian organisms age and in several chronic degenerative diseases of aging [17], [18], [19], [20], [21], [22], they may disrupt normal tissue function and drive aging phenotypes and age-related disease, including cancer.
Generally, in patients with behavioral disturbances, neuropsychiatric symptoms are chronically present.
These guidelines emphasize the fact that asthma is a chronic inflammatory disorder of the airways and that, while asthma exacerbations are episodic, airway inflammation is chronically present [ 10].
"We are chronically short at present," he said.
However, chronically implanted sensors present additional challenges associated with changes in sensor sensitivity and complexities of postrecording sensor calibrations.
It is likely that even lower levels would produce brain deficits if present chronically over long periods.
Mirtazapine may be useful for older, chronically ill patients presenting with AN and comorbid depression.
In this paper, we observed that MoDC from HCV chronically infected patients presented a defective ability to stimulate IFNγ secretion by T cells upon LPS maturation.
