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In a chronic study of selected analog (3e) in Zucker fa/fa (ZF) rat, dose-dependent decrease of body weight gain and plasma fatty acid desaturation index (DI) in both C16 and C18 are also demonstrated.
Acute toxicity in terms of the EC50 value for Daphnia or the LC50 value for fish was correlated with the respective NOEC form the chronic study of the same substance.
In the chronic study of changes in rat liver ALDH activity in which kynurenine metabolites were administered daily for 8 days, changes in body weights were also recorded.
After a 28 days chronic study of C. asiatica (three doses, administered twice daily) on type 2 diabetic rats, 1000 mg/Kg dose showed significant reduction in serum glucose level (p < 0.05; Figure 4).
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Repeated subcutaneous (s.c). injection is a common route of administration in chronic studies of neuroactive compounds.
There are no chronic studies of Penta.
There are no safety issues identified in acute and chronic studies of oral and dermal exposure to the proanthocyanidin extract in animal studies [ 59].
Chronic studies of phage for a period of 21 days were carried out on STZ induced mice; results are shown in Table 1.
Moreover, in chronic studies of transgenic mice with specific immune cell deficiencies, similar migratory cells outside of germinal centers and around small vessels contained abnormal PrP in the submucosal interstitium of the gut.
In a chronic study, the effect of PO caffeine (5 and 20 mg/kg) on alcohol intake over a 10-day period was tested.
Neither the %RS nor the ejection fraction changed significantly at the time of the chronic study in the patients who could not be acutely recanalized.
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