To this end, a single-dose study will not be sufficient in a registration trial, and at least two administrations of the study drug will be required because otherwise an acute-on-chronic phenomenon cannot be excluded.
To this regard, evidence in literature suggest that the high metabolic activity detected in this region after 24 h of pilocarpine administration may reflect a sustained increase in inhibitory activity for seizure control, taking part in the chronic epileptic phenomena [29].
The patient's medical history reported: Raynaud phenomenon, chronic gastritis and dysphagia, hepatitis C virus infection, hyperhomocystenemia, homozygosis for MTHFR 677C factor.
The movie Concussion describes a particular phenomenon, Chronic Traumatic Encephalopathy or CTE, which occurs in the brain after repeated high impact blows to the head.
Although secondary to a chronic change, this phenomenon has been observed in acute situations [ 24].
In fact, we could parameterize the model so that the chronic pressure-diuresis phenomenon acts as an "infinite-gain" control system, always returning pressure to its set point.
Aging results in an increase in systemic levels of inflammatory markers, indicating the presence of subtle chronic inflammation, a phenomenon known as inflammaging.
It is characterized by chronic inflammation, autoimmune phenomena and synovial hyperplasia, which lead to the progressive destruction of articular structures [ 1].
Chronicity, as a wide framework for understanding the phenomenon of chronic conditions in relation to patients, their families, communities and health systems, forces us to reconsider current models of service provision and the role of patients with regard to their condition [ 3, 4].
