Their data show that a chronic increase in HIF signalling in colon epithelial cells results in increased expression of proinflammatory mediators, the levels of which were decreased by inhibition of the HIF target gene migration inhibitory factor.
Hypertensive people, therefore, may eventually have congestive heart failure following enlargement of the heart caused by the chronic increase in arterial pressure.
"It may well be that continuous exposure to noise for a long time will eventually give rise to a chronic increase in blood pressure," said Dr. Lars Jarup, the senior author and a reader in public health at Imperial College London.
To withstand the chronic increase in intraluminal pressure, the vessel wall becomes thickened and stronger.
A chronic increase in HIF-2α leads to high turnover of the tight junction protein occludin, leading to a decrease in barrier integrity [17].
IAP is probably only one of many contributing factors to renal function, and it will be hard to dissect consequences of a slight chronic increase in IAP from other factors related to renal function loss [31].
To avoid a chronic increase in the unemployment rate, we need to subsidize the demand for labor -- achieving job creation -- rather than making it cheaper to buy capital, as investment and other tax credits would do".
However, chronic increase in intracellular ionic strength may inhibit protein synthesis and induce growth arrest [2].
A concurrent report, however, did not observe such a chronic increase in trabecular density.
Thus, these studies have not mimicked the chronic increase in adipose tissue-derived SAA in obese humans.
All operated eyes of animals treated with laser surgery displayed a consistent chronic increase in IOP (Fig 1).
