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We postulate that augmentation of mean infrarenal flow during exercise may reduce chronic flow stasis that may influence mural thrombus burden, degradation of the vessel wall, and aneurysm growth.
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Importantly, Gpr68-deficient mice display markedly impaired acute FMD and chronic flow-mediated outward remodeling in mesenteric arterioles.
Morrall et al. (2003), for example, evaluated several AE in chronic, flow-through 21-d D. magna studies where renewal frequency was titrated to account for losses due to degradation balanced against flow rates suitable for Daphnia health.
An imbalanced chronic blood flow between the donor and recipient twin through placental vascular anastomoses is the accepted pathophysiology of twin-to-twin transfusion syndrome (TTTS).
Constructs that were exposed to chronic low flow displayed high permeabilities to bovine serum albumin and 10 kDa dextran, numerous focal leaks, low size selectivity, and short lifespan of less than one week.
Integrin expression has also been targeted for in vivo nuclear imaging in myocardial infarction and remodeling and in response to VEGF therapy in chronic low flow dysfunctional myocardium [22, 23].
So, what began as a short-term solution quickly turns into a chronic cash flow shortage.
Here's the problem, one that those of us who work with people with chronic cash-flow issues fully understand.
CONCLUSIONS: Chronic low-flow myocardial hibernation can be reproduced in an animal model after partial coronary occlusion.
The purpose of this study was to explore whether chronic low-flow hibernation could be produced in swine.
Future work must include analysis of the chronic effects of flow, and should also examine how flow modulates the act of whole-tissue (e.g. choroid plexus) attachment without static incubation preceding flow.
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CEO of Professional Science Editing for Scientists @ prosciediting.com