Sentence examples for chronic expression of from inspiring English sources

Using adenoviral vectors, the CRE/loxP system and hypomorphic mice, we achieved chronic expression of two levels of TNF-α in the SN of adult mice.

Chronic expression of the ER-targeted intrabody (IB) led to partial clearance of Aβ42 deposits and interestingly, in reduced staining for a pathologic phospho-Tau epitope (Thr231).

On the contrary, chronic expression of high levels of TNF-α induced progressive neuronal loss (63% at 20 days and 75% at 100 days).

These multiple roles of miR-34a are maintained in a model of human breast cancer, in which chronic expression of miR-34a in triple-negative mesenchymal-like cells (enriched in cancer stem cells CSCs) could promote a luminal-like differentiation programme, restrict the CSC pool, and inhibit tumour propagation.

The finding that chronic high TNF-α had a slow and progressive neurodegenerative effect in the SN provides an animal model of PD mediated by the chronic expression of a single cytokine.

Sustained levels of production of this radical are directly toxic to tissues and contribute to the vascular collapse associated with septic shock, whereas chronic expression of nitric oxide radical is associated with various carcinomas and inflammatory conditions including juvenile diabetes, multiple sclerosis, arthritis, and ulcerative colitis [35].

Indeed, miR-34a chronic expression induced a restriction of the CSC pool and global reprogramming towards luminal-like differentiation, which were maintained when the miRNA was no longer provided, a condition that is sufficient to allow cancer cells to re-enter the normal cell cycle (Fig. 6).

Chronic low expression of TNF-α levels reduced the nigrostriatal neurodegeneration mediated by intrastriatal 6-hydroxydopamine administration.

In the renal tissues of rats with chronic fluorosis, expression of both Mfn1 protein and mRNA was clearly reduced, whereas that of Fis1 was elevated.

Using the triple-transgenic mouse model of Alzheimer's disease (3×Tg-AD), which develops amyloid and tau pathologies in a pattern reminiscent of human Alzheimer's disease, we initiated chronic intrahippocampal expression of IFNγ through delivery of a serotype-1 recombinant adeno-associated virus vector (rAAV1-IFNγ).

Importantly, chronic systemic expression of IL-1 also exacerbated neurodegeneration and microglial activation in the SN.