Sentence examples for chronic application from inspiring English sources

This strategy is directly applicable to HER2+ breast cancer because chronic application of HER2 inhibitors (i.e., trastuzumab and lapatinib) has been shown to lead to the up-regulation of autophagy response [ 14, 17] and survival signaling pathways, like the PI3K/Akt pathway, in breast cancer cells to promote cell survival [ 30].

The vessel remodeling can be prevented by the chronic application of 5-HT2B receptor antagonists.

To assess whether electrical stimulation of ischaemic calf muscles in claudicants causes a systemic inflammatory response and to evaluate effects of its chronic application on muscle function and walking ability.

Mean SLV329 plasma concentrations of 49 54 µg/l were actually reached by chronic application in the cirrhosis model.

Finally, the mobility of α7-nAChRs was regulated by global network activity, with chronic application of TTX resulting in increased mobility and reduced cell surface expression.

Thus, the chronic application of such drugs may be a route to normalizing the spatial and temporal resources of a neoplasm, thus preventing selection for cell migration and metastasis.

Long-term stability of probes and the opportunity to integrate them into fully implantable, wireless systems are a prerequisite for chronic applications and a transfer from fundamental neuroscientific studies into treatment options for diseases and clinical trials.

Participants concluded that resolution limits might not pose problems for chronic applications, but that acute events like myocardial infarction and stroke would be better served by higher-resolution technology.

In the present article we summarize the existing animal models that have been used to investigate the effects of acute and chronic alcohol application on the development of morphological alterations and pancreatic injury.

Lifestyle factors and chronic diseases: application of a composite risk index.

The 1% sucrose solution is used in tests performed during baseline and chronic stress application.