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Cells depleted of both GAK and CHC did not show an increased defect in microtubule outgrowth from chromosomes when compared to depletion of GAK alone (Fig. 4g).
We show that hermaphrodite worms deficient in DCC function, as well as male worms, exhibit enlarged X chromosomes when compared to wild type hermaphrodites.
Thus, the LDGs displayed a marked increase in somatic alterations on specific chromosomes when compared to either autologous normal-density neutrophils or healthy controls.
The distribution of each family is distinct among E. grandis chromosomes when compared to gene and repeats density (Additional file 2: Figure S2).
Using 3D FISH microscopy to measure the volumes of X and chromosome I territories and to measure distances between individual loci, we show that hermaphrodite worms deficient in DCC proteins have enlarged interphase X chromosomes when compared to wild type.
We found a tenfold reduction of H3K4me2 on accessory chromosomes when compared to core chromosomes (Fig. 5, Additional file 3: Figure S2; Additional file 13: Table S8), which is reflected by the much lower number of expressed genes from these chromosomes.
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Among other results, they found evidence for a higher mutation rate of the Z chromosome when compared to autosomes.
A total of 13 RGPs were identified in Kp13's chromosome when compared to the chromosomes of 342, MGH 78578 and NTUH-K2044.
H. somni strain 2336 contains a larger chromosome when compared to other Haemophilus and Histophilus strains whose genome sequences are available.
Previous works have shown a significant enrichment of prostate- and spermatogonia-specific genes on the X chromosome when compared to autosomes [ 29, 30].
Alternatively the explanation for the underrepresentation of the motif in the X chromosome might be related to the lower effective population size of this chromosome when compared to autosomes (3/4 that of autosomes).
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