Exact(7)
Ultimately, despite an at least partially functioning kinetochore-dependent mitotic checkpoint, chromosomes enter anaphase with improperly attached kinetochores and chromosome bridges that break during (or before) cytokinesis.
When bridges fragment, chromosomes enter breakage-fusion-bridge cycles that produce rearrangements and aneuploidy.
We hypothesize that missegregated chromosomes enter a degradative pathway initiated by endonucleolytic breaks.
As a result, chromosomes enter the first meiotic M phase as bivalents possessing four centromeres.
We have expanded the explanation of this observation: "We hypothesize that missegregated chromosomes enter a degradative pathway initiated by endonucleolytic breaks.
During the first mitotic division, when the maternal chromosomes enter the metaphase/anaphase transition, the improperly condensed paternal chromosome remnants fail to segregate and remain arrested in metaphase [ 7].
Similar(53)
Jewish Y chromosomes resemble those of Middle Eastern peoples, and the Jewish Diaspora is one way Middle Eastern chromosomes entered Europe.
The G1 chromosomes entered into the PFGE gel, while replicating chromosomes in HU-arrested cells were retained into the wells.
The range of chromosomes entered into the random number generator function was 1 through 21 (rats have 21 chromosomes, including a sex chromosome).
In contrast, our network and divergence time analyses suggest that R-M269 chromosomes entered the Cohanim population via several "migration" events, and do not represent a single Cohanim founding lineage.
One possible mechanism that could explain both the NDJ as well as the excess of heterologous segregations would be if the loss of sister chromatid cohesion leads to too many chromosomes entering the distributive system.
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